My Research

・Affiliation    : Chemical Biology Laboratory,
                   Department of Life Science and Biotechnology,
                   Faculty of Life and Environmental Science,
                   Shimane University, 
                   1060 Nishikawatsu-cho, Matsue, 690-8504 Japan

・Researches     : Bio-organic chemistry in action and regulation of insect hormones and insecticide resistance
・Title          : Professor
・Ph.D.          : "Mode of Action of Saligenin Cyclic Phosphates on 
                    Organophosphate-Resistant Houseflies" at Kyushu University (1990)
・Phone and FAX  : +81 29 838 6125 (laboratory, phone/FAX)
           numbers          +81 29 838 6028 (FAX at NIAS)
・Date of birth  : August 5, 1961  (at Usuki, Oita, Japan)
・E-mail         : shiotsuk(at)life.shimane-u.ac.jp
・Hobbies        : Music listening, playing, and composition


Current Researches:

  Characterizations, gene analyses, and mechanisms of activity regulations of 
proteins related to insect hormones activity and degradation during development, 
especially in molting and metamorphosis are being carried out with technics of 
biochemistry, bio-organic chemistry, and molecular biology.

1. Juvenile Hormones (JH)
 A. JH esterases
    ....Publication #84, 82, 72, 60, 57, 53, 40, 34, 32, 27
 B. JH epoxide hydrolases
    ....Publication #54, 51
 C. JH binding proteins from silkworm
                                 ....Publication #63, 59, 47, 28
 D. Enzymes for JH biosynthesis and lipid modification
                                 ....Publication #58, 29
 E. Physiology and related to virus infection   ....Publication #71, 39, 36, 33
2. Insect Growth Regulators
 F. To identify a mode of action of imidazole 
  insect growth regulator, KK-42,
                                 ....Publication #37, 30, 24 
 G. New insect growth regulators 
    ....Publication #61, 56, 45, 44, 41, 35, 26, 25
 H. Mitochondrial membrane proteins as targets 
       for pest control 
    ....Publication #88, 82, 79, 78, 75, 70, 69, 68, 67
3. Insect Endocrine System

 I. Endocrine system related with JH   ....Publication #91, 90
 J. Genetic and functional analyses of Silkworm Ras & orphan receptor
                                 ....Publication #50, 48, 31
 K. Quantification for JH and ecdysone
                                 ....Publication #62, 42, 38
 L. Regulation of phase polyphenism
                                 ....Publication #89, 86, 83, 81, 79, 76, 73, 69
4. Detoxifying Enzymes and Insecticide Resistance

 M. Genomic analyses of carboxyl/choline esterases
                                 ....Publication #87, 55, 52, 49, 46, 43, 23
 N. Genomic analyses of glutathione-S-transfeases
                                 ....Publication #77, 74, 66
 O. Mechanisms of resistance     ....Publication #85

5. Others

 Publication #65 (DNA repairment), #64 (pheomone signal)
===>My Publications (PDF)

NEW TOPICS

New publication has been added.
2023 Sep. 24
Insect growth-regulating activity of 1-benzyl-2-methylbenzimidazole derivatives on silkworms, Henmi S, Sueyoshi A, Ono H, Yamazaki T, Shiotsuki T, J. Pestic. Sci., 48, 99-106 (2023). doi.org/10.1584/jpestics.D23-010
         May 8
Characteristics of the takeout protein ce-0330 in the silkworm, Bombyx mori (Lepidoptera: Bombycidae), Shiotsuki T, Suzuki R, Tsuchiya W, Yamazaki T, Shimomura M, Tsubota T, Nakakura T, Henmi S, Appl. Entomol. Zool., 58, 237-244 (2023). doi:10.1007/s13355-023-00827-8
         Mar. 3
Controlled expression of nicotinic acetylcholine receptor-encoding genes in insects uncovers distinct mechanisms of action of the neonicotinoid insecticide dinotefuran, Ozoe Y, Matsubara Y, Takaka Y, Yoshioka Y, Ozoe F, Shiotsuki T, Nomura K, Nakao T, Banba S, Pestic. Biochem. Physiol., 191, 105378 (2023). doi:10.1016/j.pestbp.2023.105378
2022 Aug. 12
Characterization of E93 in neometabolous thrips Frankliniella occidentalis and Haplothrips brevitubus., Suzuki Y, Shiotsuki T, Jouraku A, Miura K, Minakuchi C, PLoS One, 16, e0254963 (2021). doi:10.1371/journal.pone.0254963
2021 Mar. 11
Ovicidal activity of juvenile hormone mimics in the bean bug, Riptortus pedestris., Naruse S, Ogino M, Nakagawa T, Yasuno Y, Jouraku A, Shiotsuki T, Shinada T, Miura K, Minakuchi C, J. Pestic. Sci, 46, 60-67 (2021). doi: 10.1584/jpestics.d20-075
2020 Feb. 23
Sex-specific expression profiles of ecdysteroid biosynthesis and ecdysone response genes in extreme sexual dimorphism of the mealybug Planococcus kraunhiae (Kuwana)., Muramatsu M, Tsuji T, Tanaka S, Shiotsuki T, Jouraku A, Miura K, Vea IM, Minakuchi C., PLoS One, 15, e0231451 (2020). doi:10.1371/journal.pone.0231451
         Feb. 23
Recombinant yellow protein of the takeout family and albino-related takeout protein specifically bind to lutein in the desert locust., Sugahara R, Tsuchiya W, Yamazaki T, Tanaka S, Shiotsuki T, Biochem Biophys Res Commun., , 522, 876-880 (2020). doi:10.1016/j.bbrc.2019.11.113
2019 Feb. 14
E93 expression and links to the juvenile hormone in hemipteran mealybugs with insights on female neoteny., Vea IM, Tanaka S, Tsuji T, Shiotsuki T, Jouraku A, Minakuchi C., Insect Biochem. Mol. Biol., 104, 65-72. (2019). doi:10.1016/j.ibmb.2018.11.008
2018 Jul. 5
CRISPR/Cas9-based heritable targeted mutagenesis in Thermobia domestica: A genetic tool in an apterygote development model of wing evolution., Ohde T, Takehana Y, Shiotsuki T, Niimi T., Arthropod Struct. Dev., 47, 362-369 (2018). doi:10.1016/j.asd.2018.06.003
         May 12
Identification of a transcription factor that functions downstream of corazonin in the control of desert locust gregarious body coloration., Sugahara R, Tanaka S, Jouraku A, Shiotsuki T., Insect Biochem. Mol. Biol., 97, 10-18 (2018). doi:10.1016/j.ibmb.2018.04.004
         Jan. 10
Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae, Shiomi K, Watanabe Y, Asami Y, Narusawa S, Hashimoto S, Iwatsuki M, Nonaka K, Shinohara Y, Shiotsuki T, Ichimaru N, Miyoshi H, Omura S. and Shiomi K., Nature Ecol. Evol., 71, 146-148 (2018). doi:10.1038/s41559-017-0314-4
2017 Oct. 11
Genomic adaptation to polyphagy and insecticides in a major East Asian noctuid pest, Cheng T, Wu J, Wu Y, Chilukuri RV, Huang L, Yamamoto K, Li F, Li W, Chen Z, Guo H, Liu J, Li S, Wang X, Li P, Liu D, Guo Y, Fu B, Li Z, Liu C, Chen Y, Tomar A, Hilliou F, Montagne N, Jacqin-Joly E, d’Alencon E, Seth RK, Bhatnagar RK, Jouraku A, Shiotsuki T, Kadono-Okuda K, Promboon A, Smagge G, Arunkumar KP, Kishino H, Goldsmith MR, Feng Q, Xia Q and Mita K, Nature Ecol. Evol., 1, 1747-1756 (2017). doi:10.1038/s41559-017-0314-4
         Sep. 1
RNAi-mediated knockdown of SPOOK reduces ecdysteroid titers and causes precocious metamorphosis in the desert locust Schistocerca gregaria, Sugahara R, Tanaka S, and Shiotsuki T, Dev. Biol., 429, 71-80 (2017). doi:10.1016/j.ydbio.2017.07.007